Sodium borohydride → HCID 57810576, compound

HRID 2106487Notes

Reaction equation

HRID 2106487 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[C:14]([CH3:15])=[CH:13][C:12]([C:16]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH2:28][C:29](=[O:34])[C:30]([CH3:33])([CH3:32])[CH3:31])=[C:23]([CH2:35]C)[CH:22]=3)([CH2:19][CH3:20])[CH2:17][CH3:18])=[CH:11][C:9]=2[CH:10]=1)=[O:5])[CH3:2].[BH4-].[Na+]>C1COCC1>[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[C:14]([CH3:15])=[CH:13][C:12]([C:16]([CH2:19][CH3:20])([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH2:28][CH:29]([OH:34])[C:30]([CH3:32])([CH3:31])[CH3:33])=[C:23]([CH3:35])[CH:22]=3)[CH2:17][CH3:18])=[CH:11][C:9]=2[CH:10]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 68813362HCID 68813362, compound

Product 1

HCID 57810576HCID 57810576, compoundYield 68.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-{1-[4-(3,3-Dimethyl-2-oxo-butoxy)-3-ethyl-phenyl]-1-ethyl-propyl}-7-methyl-benzofuran-2-carboxylic acid ethyl ester (1.87 g, 3.91 mmol) in THF (50 mL) is reacted with NaBH4 (0.45 g, 11.7 mmol) analogous to Example 22 to obtain the title compound (1.28 g, 68%).

Sources & evidence

ORD record
ord-28b958c0172741e881d9ae896fae3396
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

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