Potassium Carbonate → HCID 11178032, compound

HRID 2106493Notes

Reaction equation

HRID 2106493 reaction equation
[CH2:1]([C:3]([C:14]1[CH:15]=[C:16](C)[C:17]2[O:21][C:20]([C:22]([OH:24])=[O:23])=[CH:19][C:18]=2[CH:25]=1)([C:6]1[CH:11]=[CH:10][C:9](O)=[C:8]([CH3:13])[CH:7]=1)[CH2:4][CH3:5])[CH3:2].Cl[CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][C:29]1=[O:34].C(=O)([O-])[O-].[K+].[K+].[OH-:41].[Na+]>>[CH2:1]([C:3]([C:14]1[CH:15]=[CH:16][C:17]2[O:21][C:20]([C:22]([OH:24])=[O:23])=[CH:19][C:18]=2[CH:25]=1)([C:6]1[CH:11]=[CH:10][C:9]([O:41][CH:28]2[CH2:33][CH2:32][CH2:31][CH2:30][C:29]2=[O:34])=[C:8]([CH3:13])[CH:7]=1)[CH2:4][CH3:5])[CH3:2]

Participants

5

Reactant 4

HCID 11430Potassium CarbonateHCID 132032-ChlorocyclohexanoneHCID 14798Sodium HydroxideHCID 68817305HCID 68817305, compound

Product 1

HCID 11178032HCID 11178032, compound

Procedure

5-[1-Ethyl-1-(4-hydroxy-3-methyl-phenyl)-propyl]-7-methyl-benzofuran-2-carboxylic acid (1000 mg, 2.7 mmol), 2-chloro cyclohexanone (429 mg, 3.3 mmol) and potassium carbonate (759 mg, 5.5 mmol) was made in an analogous manner to Example 30 part D followed by base hydrolysis with 2N NaOH analogous to Example 30 part E to yield (60 mg, 30%) MS (ES) m/e: 433.3 (M−1)

Workup

  1. customto yield (60 mg, 30%)

Sources & evidence

ORD record
ord-9d63440a95634e8ea47dfcbc3bb189e2
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

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