Lithium Hydroxide → HCID 57807313, compound

HRID 2106550Notes

Reaction equation

HRID 2106550 reaction equation
[Li+].[OH-:2].[O:3]=[C:4]1[N:10]([CH:11]2[CH2:16][CH2:15][N:14]([C:17]([O:19][C@H:20]([CH2:43][C:44]3[CH:49]=[C:48]([C:50]([F:53])([F:52])[F:51])[C:47]([NH2:54])=[C:46]([Cl:55])[CH:45]=3)[C:21]([N:23]3[CH2:28][CH2:27][N:26]([CH:29]4[CH2:35][CH:34]5[N:36](C(OCC)=O)[C:31](C)([CH2:32][CH2:33]5)[CH2:30]4)[CH2:25][CH2:24]3)=[O:22])=[O:18])[CH2:13][CH2:12]2)[CH2:9][CH2:8][C:7]2[CH:56]=[CH:57][CH:58]=[CH:59][C:6]=2[NH:5]1.[CH2:60]1[CH2:64][O:63]CC1>O>[O:3]=[C:4]1[N:10]([CH:11]2[CH2:12][CH2:13][N:14]([C:17]([O:19][C@H:20]([CH2:43][C:44]3[CH:49]=[C:48]([C:50]([F:52])([F:53])[F:51])[C:47]([NH2:54])=[C:46]([Cl:55])[CH:45]=3)[C:21]([N:23]3[CH2:28][CH2:27][N:26]([CH:29]4[CH2:35][CH:34]5[N:36]([CH2:60][C:64]([OH:2])=[O:63])[CH:31]([CH2:32][CH2:33]5)[CH2:30]4)[CH2:25][CH2:24]3)=[O:22])=[O:18])[CH2:15][CH2:16]2)[CH2:9][CH2:8][C:7]2[CH:56]=[CH:57][CH:58]=[CH:59][C:6]=2[NH:5]1

Participants

5

Reactant 3

HCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 66941746HCID 66941746, compound

Product 1

HCID 57807313HCID 57807313, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 1.92 mg (0.08 mmol) LiOH in 1 mL water was added to 40.0 mg (0.05 mmol) (R)-1-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-2-[4-(8-ethoxycarbonyl-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-piperazin-1-yl]-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate in 1 mL THF and the reaction mixture was shaken overnight at RT. The solvents were eliminated in a nitrogen stream and the residue was purified by HPLC; the fractions containing the product were combined and lyophilised.

Workup

  1. customthe residue was purified by HPLC
  2. additionthe fractions containing the product

Sources & evidence

ORD record
ord-971677a1224843d1849b6ef7bbbb0584
Source dataset
uspto-grants-2009_08
Patent number
US07579341B2

Reaction notes

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