Methanol → HCID 14268788, compound

HRID 2106572Notes

Reaction equation

HRID 2106572 reaction equation
[Na].CO.[Cl:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH:15]=[N:14][C:13]([OH:16])=[N:12]1.Br[CH:18]([CH3:24])[C:19]([O:21][CH2:22][CH3:23])=[O:20]>CS(C)=O>[Cl:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH:15]=[N:14][C:13]([O:16][CH:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH3:24])=[N:12]1

Participants

6

Reactant 4

HCID 887MethanolHCID 79040Ethyl 2-bromopropionateHCID 5360545SodiumHCID 178517974HCID 178517974, compound

Product 1

HCID 14268788HCID 14268788, compoundYield 92.6%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The process was carried out essentially according to that of Example 2 above, starting with 1.2 g of sodium, 30 ml of methanol, 10 g of 1-(2-chlorophenyl)-3-hydroxy-1,2,4-1H-triazole and 9.3 g of ethyl 2-bromopropionate. The solvent was 100 ml of dimethylsulfoxide. The product obtained was 14 g of the desired product, an oil.

Workup

  1. customThe product obtained

Sources & evidence

ORD record
ord-8dbed60f8879495d9a34f6a52b772c60
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

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