Methanol → HCID 15016253, compound

HRID 2106578Notes

Reaction equation

HRID 2106578 reaction equation
[Na].CO.[OH:4][C:5]1[N:9]=[CH:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)[N:6]=1.Br[CH:18]([CH3:24])[C:19]([O:21][CH2:22][CH3:23])=[O:20]>CS(C)=O>[CH2:22]([O:21][C:19]([CH:18]([O:4][C:5]1[N:9]=[CH:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)[N:6]=1)[CH3:24])=[O:20])[CH3:23]

Participants

6

Reactant 4

HCID 887MethanolHCID 79040Ethyl 2-bromopropionateHCID 5360545SodiumHCID 178426256HCID 178426256, compound

Product 1

HCID 15016253HCID 15016253, compoundYield 28.7%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The process was carried out as described in Example 8, starting with 1.1 g of sodium, 20 ml of methanol, 150 ml of dimethylsulfoxide, 8.5 g of 3-hydroxy-1-(4-methylphenyl)-1,2,4-1H-triazole and 8.7 g of ethyl 2-bromopropionate. A yield of 3.8 g of the desired product, m.p. 69°-71°, was obtained.

Sources & evidence

ORD record
ord-0d88956555c6460986db142a54cc4a8e
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

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