Ethanol → HCID 15016259, compound

HRID 2106582Notes

Reaction equation

HRID 2106582 reaction equation
[Na].C(O)C.[Br:5][C:6]1[CH:7]=[C:8]([N:12]2[CH:16]=[N:15][C:14]([OH:17])=[N:13]2)[CH:9]=[CH:10][CH:11]=1.Br[CH:19]([CH3:25])[C:20]([O:22][CH2:23][CH3:24])=[O:21]>CS(C)=O>[Br:5][C:6]1[CH:7]=[C:8]([N:12]2[CH:16]=[N:15][C:14]([O:17][CH:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH3:25])=[N:13]2)[CH:9]=[CH:10][CH:11]=1

Participants

6

Reactant 4

HCID 702EthanolHCID 79040Ethyl 2-bromopropionateHCID 5360545SodiumHCID 178517961HCID 178517961, compound

Product 1

HCID 15016259HCID 15016259, compoundYield 77.4%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The process was carried out as described in Example 3, starting with 2.8 g of sodium, 50 ml of ethanol, 75 ml of dimethylsulfoxide, 29 g of 1-(3-bromophenyl)-3-hydroxy-1,2,4-1H-triazole and 21.9 g of ethyl 2-bromopropionate. The yield was 31.8 g of the desired product, m.p. 83°-85°.

Sources & evidence

ORD record
ord-f5fb8ea5271b4e3dacde34b057c6e5ae
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

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