Dimethylamine → HCID 15016285, compound

HRID 2106603Notes

Reaction equation

HRID 2106603 reaction equation
[C:1]([CH:4]([O:6][C:7]1[N:11]=[CH:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)[N:8]=1)[CH3:5])([OH:3])=O.[C:19](N1C=CN=C1)([N:21]1C=CN=[CH:22]1)=O.CNC>>[Cl:18][C:14]1[CH:13]=[C:12]([N:9]2[CH:10]=[N:11][C:7]([O:6][CH:4]([C:1]([N:21]([CH3:22])[CH3:19])=[O:3])[CH3:5])=[N:8]2)[CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 3

HCID 674DimethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 15016263HCID 15016263, compound

Product 1

HCID 15016285HCID 15016285, compoundYield 66.6%

Procedure

The process was carried out as was Example 45, starting with 3 g of the compound of Example 25, 2.7 g of carbonyldiimidazole and 3.6 ml of 40% aqueous dimethylamine. The product was recrystallized from toluene to obtain 2.2 g of desired product, m.p. 136°-139°.

Workup

  1. customThe product was recrystallized from toluene

Sources & evidence

ORD record
ord-e351cb6b7bb04e08b77b2ea9cb3f0145
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

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