Methylamine → HCID 15016287, compound

HRID 2106606Notes

Reaction equation

HRID 2106606 reaction equation
[C:1]([CH:4]([O:6][C:7]1[N:11]=[CH:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[N:8]=1)[CH3:5])([OH:3])=O.[C:22](N1C=CN=C1)([N:24]1C=CN=C1)=O.CN>>[CH3:22][NH:24][C:1]([CH:4]([O:6][C:7]1[N:11]=[CH:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[N:8]=1)[CH3:5])=[O:3]

Participants

4

Reactant 3

HCID 6329MethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 15016262HCID 15016262, compound

Product 1

HCID 15016287HCID 15016287, compound

Procedure

The process was carried out as was Example 45, starting with 3 g of the compound of Example 24, 3.4 g of carbonyldiimidazole and 3 ml of 40% aqueous methylamine. The product was not recrystallized, and amounted to 2.7 g of the desired product, m.p. 137°-139°.

Workup

  1. customThe product was not recrystallized

Sources & evidence

ORD record
ord-3e8cd3d7a611494ea054f8f2fe60d7ea
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

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