Ammonium Hydroxide → HCID 15016289, compound

HRID 2106608Notes

Reaction equation

HRID 2106608 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[N:11][C:10]([O:13][CH:14]([C:16]([OH:18])=O)[CH3:15])=[N:9]2)=[CH:4][CH:3]=1.C(N1C=CN=C1)([N:21]1C=CN=C1)=O.[OH-].[NH4+]>>[NH2:21][C:16]([CH:14]([O:13][C:10]1[N:11]=[CH:12][N:8]([C:5]2[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=2)[N:9]=1)[CH3:15])=[O:18]

Participants

4

Reactant 3

HCID 14923Ammonium HydroxideHCID 682631,1'-CarbonyldiimidazoleHCID 15016275HCID 15016275, compound

Product 1

HCID 15016289HCID 15016289, compoundYield 53.5%

Procedure

The process was carried out as was Example 45, starting with 3 g of the compound of Example 37, 2.6 g of carbonyldiimidazole and 0.7 g of ammonium hydroxide. The product was recrystallized from ethanol to obtain 1.6 g of the desired product, m.p. 179°-181°.

Workup

  1. customThe product was recrystallized from ethanol

Sources & evidence

ORD record
ord-86e7c9b5fb324f2b983143f7eed43034
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

Loading…