Methylamine → HCID 15016290, compound

HRID 2106609Notes

Reaction equation

HRID 2106609 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[N:11][C:10]([O:13][CH:14]([C:16]([OH:18])=O)[CH3:15])=[N:9]2)=[CH:4][CH:3]=1.[C:19](N1C=CN=C1)([N:21]1C=CN=C1)=O.CN>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[N:11][C:10]([O:13][CH:14]([C:16]([NH:21][CH3:19])=[O:18])[CH3:15])=[N:9]2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 15016275HCID 15016275, compound

Product 1

HCID 15016290HCID 15016290, compoundYield 80%

Procedure

The process was carried out as was Example 45, starting with 3 g of the compound of Example 37, 2.3 g of carbonyldiimidazole and 2 ml of 40% aqueous methylamine. The product was recrystallized from ethanol to obtain 2.5 g of the desired product, m.p. 176°-178°.

Workup

  1. customThe product was recrystallized from ethanol

Sources & evidence

ORD record
ord-1c3c0def01f140038baf2f0f65dc3282
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

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