Ammonium Hydroxide → HCID 15016291, compound

HRID 2106610Notes

Reaction equation

HRID 2106610 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([N:8]2[CH:12]=[N:11][C:10]([O:13][CH:14]([C:16]([OH:18])=O)[CH3:15])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.C(N1C=CN=C1)([N:21]1C=CN=C1)=O.[OH-].[NH4+]>>[NH2:21][C:16]([CH:14]([O:13][C:10]1[N:11]=[CH:12][N:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=2)[N:9]=1)[CH3:15])=[O:18]

Participants

4

Reactant 3

HCID 14923Ammonium HydroxideHCID 682631,1'-CarbonyldiimidazoleHCID 15016276HCID 15016276, compound

Product 1

HCID 15016291HCID 15016291, compoundYield 53.5%

Procedure

The process was carried out as was Example 45, starting with 3 g of the compound of Example 38, 2.3 g of carbonyldiimidazole and 0.7 g of ammonium hydroxide. A yield of 1.6 g of the desired product, in unrecrystallized form, m.p. 141°-144°, was obtained.

Sources & evidence

ORD record
ord-570e2fe4946146b999cb4192dc40072a
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

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