1,1'-Carbonyldiimidazole → HCID 15016296, compound

HRID 2106615Notes

Reaction equation

HRID 2106615 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[N:11][C:10]([O:13][CH:14]([C:16]([OH:18])=O)[CH3:15])=[N:9]2)=[CH:4][CH:3]=1.C(N1C=CN=C1)(N1C=CN=C1)=O.[CH:31]1([NH2:34])[CH2:33][CH2:32]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[N:11][C:10]([O:13][CH:14]([C:16]([NH:34][CH:31]3[CH2:33][CH2:32]3)=[O:18])[CH3:15])=[N:9]2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 69828CyclopropylamineHCID 15016275HCID 15016275, compound

Product 1

HCID 15016296HCID 15016296, compoundYield 77%

Procedure

The process was carried out according to Example 59, starting with 3 g of the compound of Example 37, 2.4 g of carbonyldiimidazole and 1.1 g of cyclopropylamine. product was recrystallized from ethanol to obtain 2.6 g of the desired product, m.p. 170°-172°.

Workup

  1. customproduct was recrystallized from ethanol

Sources & evidence

ORD record
ord-5f6abddefcdb4bae89eed97dbfebb628
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

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