2-Bromotoluene → HCID 23048955, compound

HRID 2106664Notes

Reaction equation

HRID 2106664 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:8].[Mg].[CH3:10][C:11]1[CH:15]=[CH:14][S:13][C:12]=1[CH:16]=[O:17].CCCCCCC.C1COCC1>C(OCC)C>[CH3:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[CH:16]([C:12]1[S:13][CH:14]=[CH:15][C:11]=1[CH3:10])[OH:17]

Participants

6

Reactant 4

HCID 72362-BromotolueneHCID 799113-Methyl-2-thiophenecarboxaldehydeHCID 5462224MagnesiumHCID 21263495Tetrahydrofuran heptane

Product 1

HCID 23048955HCID 23048955, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound was prepared from 2-bromotoluene (35.55 g, 0.208 mole), magnesium turnings (5.1 g, 0.208 mole) and 3-methylthiophene-2-aldehyde (23.6 g, 0.187 mole) by the method described in Example 6, using diethyl ether (150 ml) as solvent. The yield was 36.0 g (88%). T.l.c. rf=0.39 (SiO2, heptane/THF (7:3)).

Sources & evidence

ORD record
ord-38c77cf9ce8844d09bfe2f791be12e00
Source dataset
uspto-grants-1990_06
Patent number
US04931450

Reaction notes

Loading…