4-(2-DIETHYLAMINOETHYL)PIPERIDINE → HCID 14369653, compound

HRID 2106691Notes

Reaction equation

HRID 2106691 reaction equation
Cl[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3].[CH2:20]([N:22]([CH2:31][CH3:32])[CH2:23][CH2:24][CH:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1)[CH3:21]>C(OCC)(=O)C>[CH2:31]([N:22]([CH2:20][CH3:21])[CH2:23][CH2:24][CH:25]1[CH2:26][CH2:27][N:28]([C:2]([N:4]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[C:8](=[O:15])[NH:7][C:6]3[CH:16]=[CH:17][CH:18]=[N:19][C:5]2=3)=[O:3])[CH2:29][CH2:30]1)[CH3:32]

Participants

4

Reactant 2

HCID 2962944-(2-DIETHYLAMINOETHYL)PIPERIDINEHCID 1104396211-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

Product 1

HCID 14369653HCID 14369653, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Prepared analogously to Example 4 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 4-[2-(diethylamino)ethyl]piperidine in a yield of 34% of theory. Colourless crystals, m.p. 154° C. (ethyl acetate).

Sources & evidence

ORD record
ord-d8c796a2ed43470ab3f583569a0ab5a7
Source dataset
uspto-grants-1990_06
Patent number
US04931436

Reaction notes

Loading…