Hydrochloric Acid → HCID 15057352, compound

HRID 2106717Notes

Reaction equation

HRID 2106717 reaction equation
Cl[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][C:13]([CH3:15])=[CH:14][C:9]=2[C:8](=[O:16])[NH:7][C:6]2[CH:17]=[CH:18][CH:19]=[N:20][C:5]1=2)=[O:3].[N:21]1([CH2:27][CH2:28][CH:29]2[O:34][CH2:33][CH2:32][NH:31][CH2:30]2)[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1.Cl>>[CH3:15][C:13]1[CH:12]=[CH:11][C:10]2[N:4]([C:2]([N:31]3[CH2:32][CH2:33][O:34][CH:29]([CH2:28][CH2:27][N:21]4[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]4)[CH2:30]3)=[O:3])[C:5]3[N:20]=[CH:19][CH:18]=[CH:17][C:6]=3[NH:7][C:8](=[O:16])[C:9]=2[CH:14]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 1420997711-(chlorocarbonyl)-5,11-dihydro-8-methyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 150573272-[2-(1-Piperidinyl)ethyl]morpholine

Product 1

HCID 15057352HCID 15057352, compoundYield 79%

Procedure

Prepared analogously to Example 4 from 11-(chlorocarbonyl)-5,11-dihydro-8-methyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[2-(1-piperidinyl)ethyl]morpholine in a yield of 79% of theory. Rf 0.43 (conditions as in Example 58). The colourless hydrochloride melted at 272°-273° C. with decomposition.

Sources & evidence

ORD record
ord-2e64fc64377c4369913e4620c844e26c
Source dataset
uspto-grants-1990_06
Patent number
US04931436

Reaction notes

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