反应详情

To a solution of 2-naphthol (7 g) in 50 ml dimethylformamide was added sodium carbonate (10 g), followed by 3-fluoro-4-nitropyridine-N-oxide. After stirring three hours at ambient temperature the reaction mixture was stirred with water and extracted with ethyl acetate. The organic extract was washed with water and saturated sodium chloride solution, dried (anhy. MgSO4), filtered and concentrated to a solid. This solid was triturated with ether, collected and dried to give a solid, 11.6 g, m.p. 130°-133° C. A three gram portion was recrystallized from ethanol to give crystals, 2.8 g, m.p. 131°-133° C.

1. extractionextracted with ethyl acetate
2. extractionThe organic extract
3. washwas washed with water and saturated sodium chloride solution
4. customdried (anhy
5. filtrationMgSO4), filtered
6. concentrationconcentrated to a solid
7. customThis solid was triturated with ether
8. customcollected
9. customdried
10. customto give a solid, 11.6 g, m.p. 130°-133° C
11. customA three gram portion was recrystallized from ethanol
12. customto give crystals, 2.8 g, m.p. 131°-133° C.