反应详情

To a stirred solution of 10.8 parts of 4-[4-(4-aminophenyl)-1-piperazinyl]phenol in 3.2 parts of pyridine and 90 parts of N,N-dimethylformamide was added dropwise a solution of 3.1 parts of acetyl chloride in 27 parts of methylbenzene at 20° C. (exothermic reaction). Upon completion, stirring was continued for 1 hour at 20° C. The reaction mixture was poured into water while stirring. The product was filtered off, washed with water and dissolved in a mixture of trichloromethane and methanol (3:1 by volume). The whole was purified by column chromatography over silica gel using a mixture of trichloromethane and methanol (95:5 by volume) as eluent. The second fraction was collected and the eluent was evaporated. The residue was crystallized from a mixture of ethanol and methylbenzene (1:1 by volume)+(activated charcoal). The produce was filtered off and dried yielding 5.3 parts (42.5%) of N-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]acetamide; mp. 256.2° C. (compound 1.03).

1. custom(exothermic reaction)
2. stirringwhile stirring
3. filtrationThe product was filtered off
4. washwashed with water
5. dissolutiondissolved in a mixture of trichloromethane and methanol (3:1 by volume)
6. customThe whole was purified by column chromatography over silica gel using
7. additiona mixture of trichloromethane and methanol (95:5 by volume) as eluent
8. customThe second fraction was collected
9. customthe eluent was evaporated
10. customThe residue was crystallized from a mixture of ethanol and methylbenzene (1:1 by volume)+(activated charcoal)
11. filtrationThe produce was filtered off
12. customdried