2,6-Xylyl isocyanate → Ethyl 2-[3-(2,6-xylyl)ureido]thiazol-4-ylglyoxylate

HRID 2107248Notes

Reaction equation

HRID 2107248 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[C:14]1([N:22]=[C:23]=[O:24])[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=1[CH3:20]>CN(C)C=O>[C:14]1([NH:22][C:23](=[O:24])[NH:1][C:2]2[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=1[CH3:20]

Participants

4

Reactant 2

HCID 987872,6-Xylyl isocyanateHCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

Product 1

HCID 15053505Ethyl 2-[3-(2,6-xylyl)ureido]thiazol-4-ylglyoxylate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following a procedure similar to that described in Preparation 1, the desired compound was prepared from 5 g of ethyl 2-aminothiazol-4-ylglyoxylate, 5.5 g of 2,6-xylyl isocyanate and 30 ml of dimethylformamide. The resulting product was a pale yellow powder having the following physical properties.

Workup

  1. customthat described in Preparation 1

Sources & evidence

ORD record
ord-b75385a1c230444bb9c16139a3165f3b
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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