1,1'-Carbonyldiimidazole → HCID 23047639, compound

HRID 2107254Notes

Reaction equation

HRID 2107254 reaction equation
[C:1](N1C=CN=C1)([N:3]1[CH:7]=[CH:6][N:5]=[CH:4]1)=[O:2].[NH2:13][C:14]1[S:15][CH:16]=[C:17]([C:19](=[O:25])[C:20]([O:22][CH2:23][CH3:24])=[O:21])[N:18]=1>O1CCCC1>[N:3]1([C:1]([NH:13][C:14]2[S:15][CH:16]=[C:17]([C:19](=[O:25])[C:20]([O:22][CH2:23][CH3:24])=[O:21])[N:18]=2)=[O:2])[CH:7]=[CH:6][N:5]=[CH:4]1

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

Product 1

HCID 23047639HCID 23047639, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture comprising 25 g of carbonyldiimidazole, 30.87 g of ethyl 2-aminothiazol-4-ylglyoxylate and 300 ml of tetrahydrofuran was stirred at room temperature for 1 day. After completion of the reaction, the crystals which precipitated out were collected by filtration and washed with ethyl acetate to give crude ethyl 2-(1-imidazolylcarbonylamino)thiazol-4-ylglyoxylate.

Workup

  1. customAfter completion of the reaction
  2. customthe crystals which precipitated out
  3. filtrationwere collected by filtration
  4. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-25b2837c23e1485c827f3109b7938b77
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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