Triethylamine → HCID 23047606, compound

HRID 2107264Notes

Reaction equation

HRID 2107264 reaction equation
[C:1]1([CH3:15])[C:2]([NH:7][C:8]2[S:9][CH:10]=[C:11]([CH2:13][OH:14])[N:12]=2)=[CH:3][CH:4]=[CH:5][CH:6]=1.C(N(CC)CC)C>CS(C)=O>[C:1]1([CH3:15])[C:2]([NH:7][C:8]2[S:9][CH:10]=[C:11]([CH:13]=[O:14])[N:12]=2)=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 16769476HCID 16769476, compound

Product 1

HCID 23047606HCID 23047606, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Following a procedure similar to that described in Preparation 44, the desired compound was prepared from 6.12 g of 2-(o-toluidino)thiazole-4-ylmethanol, 13.2 g of a sulfur trioxide pyridine complex, 12 ml of triethylamine and 210 ml of dimethyl sulfoxide, as pale brown prismatic crystals having the following physical properties.

Workup

  1. customthat described in Preparation 44

Sources & evidence

ORD record
ord-f4d5b64d9b4944fab3df556a8f2e963a
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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