反应详情

温度

60 °C

A mixture comprising 3.5 g of 2-anilinothiazole-4-carbaldehyde, 6.5 g of (ethoxycarbonylmethylene)triphenylphosphorane and 35 ml of tetrahydrofuran was heated at 60 ° C. for 2 hours. The reaction mixture was poured into water and extracted with benzene. The benzene extract was dried over anhydrous sodium sulfate, and the solvent was evaporated off under reduced pressure, giving an oil. This oil was purified by silica gel column chromatography. using as eluent a 9:1 mixture of benzene and ethyl acetate, giving the desired compound as yellow crystals.

1. extractionextracted with benzene
2. extractionThe benzene extract
3. dry with materialwas dried over anhydrous sodium sulfate
4. customthe solvent was evaporated off under reduced pressure
5. customgiving an oil
6. customThis oil was purified by silica gel column chromatography
7. additiona 9:1 mixture of benzene and ethyl acetate