Ethyl 2-(cyclohexylamino)-1,3-thiazole-4-carboxylate → 2-Cyclohexylaminothiazol-4-ylmethanol

HRID 2107285Notes

Reaction equation

HRID 2107285 reaction equation
[CH:1]1([NH:7][C:8]2[S:9][CH:10]=[C:11]([C:13](OCC)=[O:14])[N:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH:1]1([NH:7][C:8]2[S:9][CH:10]=[C:11]([CH2:13][OH:14])[N:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 15053542Ethyl 2-(cyclohexylamino)-1,3-thiazole-4-carboxylateHCID 21226445Aluminium lithium hydride

Product 1

HCID 150535602-Cyclohexylaminothiazol-4-ylmethanol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The reaction described in Preparation 15 was repeated, but using 19 g of ethyl 2-cyclohexylaminothiazole-4-carboxylate, 4.2 g of lithium aluminum hydride and 250 ml of tetrahydrofuran, giving the title compound as pale yellow needles.

Workup

  1. customThe reaction described in Preparation 15

Sources & evidence

ORD record
ord-89bae77397e94dfe9821863506d66151
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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