Triethylamine → 2-(Morpholin-4-yl)-1,3-thiazole-4-carbaldehyde

HRID 2107290Notes

Reaction equation

HRID 2107290 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[S:8][CH:9]=[C:10]([CH2:12][OH:13])[N:11]=2)[CH2:3][CH2:2]1.C(N(CC)CC)C>CS(C)=O>[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[S:8][CH:9]=[C:10]([CH:12]=[O:13])[N:11]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 10608093[2-(Morpholin-4-yl)-1,3-thiazol-4-yl]methanol

Product 1

HCID 150535792-(Morpholin-4-yl)-1,3-thiazole-4-carbaldehyde

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The reaction described in Preparation 44 was repeated but using 2.4 g of 2-morpholinothiazol-4-ylmethanol, 5.7 g of sulfur trioxide pyridine complex. 3.6 g of triethylamine and 30 ml of dimethyl sulfoxide, giving the title compound as pale yellow needles.

Workup

  1. customThe reaction described in Preparation 44

Sources & evidence

ORD record
ord-d26199f514254cbfbaf176d910527013
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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