Octylamine → Ethyl 2-(octylamino)-1,3-thiazole-4-carboxylate

HRID 2107299Notes

Reaction equation

HRID 2107299 reaction equation
[CH2:1]([NH2:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].Cl[C:11]1[S:12][CH:13]=[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[N:15]=1.C(N(CC)CC)C>CN(C)C=O>[CH2:1]([NH:9][C:11]1[S:12][CH:13]=[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[N:15]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

5

Reactant 3

HCID 8143OctylamineHCID 8471TriethylamineHCID 13106141Ethyl 2-chlorothiazole-4-carboxylate

Product 1

HCID 15053548Ethyl 2-(octylamino)-1,3-thiazole-4-carboxylate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The reaction described in Preparation 26 was repeated, but using 2.7 g of octylamine, 4.0 g of ethyl 2-chlorothiazole-4-carboxylate, 4.2 g of triethylamine and 15 ml of dimethylformamide, giving the title compound as a pale yellow oil.

Workup

  1. customThe reaction described in Preparation 26

Sources & evidence

ORD record
ord-f21749dcd6544948b16e1f2d5e4bd699
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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