huagongshe.com
HRID2107784

反应详情

EQUATION

反应方程式

HRID 2107784 的结构方程式

REACTANTS

反应物

6
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：C[C@@H](O)[C@H](N)C(=O)O
HCID6288

DL-Threonine

C4H9NO3

结构：C1COCCO1
HCID31275

1,4-Dioxane

C4H8O2

结构：CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O
HCID85083

1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-

C10H17NO4

结构：O=C([O-])O.[Na+]
HCID516892

Sodium Bicarbonate

CHNaO3

结构：CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)ON1C(=O)CCC1=O
HCID853883

未命名化合物

2 次

PRODUCTS

生成物

1
结构：C[C@@H](OCc1ccccc1)[C@H](NC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)C(=O)O
HCID14836683

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Boc-Pro-Thr(OBzl)-OH was prepared by coupling Boc-Pro-OSu (the N-hydroxysuccinamide ester of Boc-Pro-OH) to H-Thr (OBzl) - OH. H-Thr (OBzl)-OH.HCL was dissolved in 25 ml of water, NaHCO3 (6.21 g, 73.9 mmoles) and a solution of Boc-Pro-Osu (5.07 g, 16.25 mmoles) in 25 ml of dioxane were added. After stirring 3 hours, the reaction mixture was acidified with hydrochloric acid and the product extracted into ethyl acetate. It was washed with 0.2N HCl prepared in saturated aqueous NaCl, saturated NaCl and dried over anhydrous Na2SO4. Solvent was evaporated to yield 6.24 g (mp 120°-12.5°).

WORKUP

后处理

  1. extractionthe product extracted into ethyl acetate
  2. washIt was washed with 0.2N HCl
  3. customprepared in saturated aqueous NaCl
  4. dry with materialsaturated NaCl and dried over anhydrous Na2SO4
  5. customSolvent was evaporated
  6. customto yield 6.24 g (mp 120°-12.5°)