Hydrochloric Acid → HCID 15113952, compound

n-Butyl lithium (a 2.5M solution in hexane; 4.37 ml, 10.9 mmol) was added to a solution of morpholine (0.91 ml, 10.9 mmol) in tetrahydrofuran (30 ml) at -78° under argon. After 20 min., 3-furaldehyde (0.9 ml, 10.4 mmol) was added. After another 20 min., sec-butyl lithium (a 1.3M solution in cyclohexane; 8.4 ml, 10.9 mmol) was added dropwise and stirring continued at -78° for 7 hours before 1-hexanal (1.31 ml, 10.9 mmol) was added. Stirring was continued overnight (16 hours) while the cooling bath was allowed to attain room temperature. The solution was poured into ice cold 10% (v/v) hydrochloric acid (30 ml) and after stirring at 0° for 10 min., the layers were separated. The aqueous phase was extracted with diethyl ether. All the organic phases were combined, dried (magnesium sulfate) and evaporated down to give a brown oil, which was purified by flash chromatography on silica using 40% ethyl ether/hexane. Fractions with Rf of about 0.08 on evaporation gave the title compound as a yellow oil.

1. waitAfter another 20 min.
2. addition8.4 ml, 10.9 mmol) was added dropwise
3. additionwas added
4. stirringStirring
5. waitwas continued overnight
6. custom(16 hours)
7. customto attain room temperature
8. stirringafter stirring at 0° for 10 min.
9. customthe layers were separated
10. extractionThe aqueous phase was extracted with diethyl ether
11. dry with materialdried (magnesium sulfate)
12. customevaporated down
13. customto give a brown oil, which
14. customwas purified by flash chromatography on silica using 40% ethyl ether/hexane
15. customFractions with Rf of about 0.08 on evaporation

ORD record

ord-6ee21351135349c9b55af6cb26ff6f5c

Source dataset

uspto-grants-1990_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04935530