Acetic Acid → HCID 14075369, compound

HRID 2107918Notes

Reaction equation

HRID 2107918 reaction equation
[C:1]1([C:7]2O[C:9]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:10][C:11](=[O:17])[C:12]=2[C:13]([O:15][CH3:16])=[O:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO.[CH3:26][NH2:27].C(O)(=O)C>O>[C:1]1([C:7]2[N:27]([CH3:26])[C:9]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:10][C:11](=[O:17])[C:12]=2[C:13]([O:15][CH3:16])=[O:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 887MethanolHCID 6329MethylamineHCID 14075269HCID 14075269, compound

Product 1

HCID 14075369HCID 14075369, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.0 gms of 2,6-diphenyl-3-methoxycarbonyl-pyr-4-one, 33 mls of methanol, 13.3 mls of 40% aqueous methylamine and 2 mls of glacial acetic acid were mixed at room temperature. The next day the mixture was diluted with water. Filtration of the resulting suspension yielded 2.5 gms of methyl 2,6-diphenyl-1-methyl-4-oxonicotinate. Recrystallization from methanol provided material at 255°-7°.

Workup

  1. filtrationFiltration of the resulting suspension

Sources & evidence

ORD record
ord-86b36515f1c64df9a14d08793d66a84a
Source dataset
uspto-grants-1990_06
Patent number
US04936904

Reaction notes

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