Hydrochloric Acid → HCID 15718250, compound

HRID 2107965Notes

Reaction equation

HRID 2107965 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([CH3:37])=[C:5]([C:33]([O:35][CH3:36])=[O:34])[CH:6]([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([N+:30]([O-:32])=[O:31])[CH:25]=2)[C:7]=1[C:8]([O:10][CH2:11][C:12]([CH3:23])([CH3:22])[CH2:13][N:14]1[CH2:19][CH2:18][N:17](C=O)[CH2:16][CH2:15]1)=[O:9].C(O)C.Cl.C(OC(C)C)(C)C>CO>[CH3:1][C:2]1[NH:3][C:4]([CH3:37])=[C:5]([C:33]([O:35][CH3:36])=[O:34])[CH:6]([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([N+:30]([O-:32])=[O:31])[CH:25]=2)[C:7]=1[C:8]([O:10][CH2:11][C:12]([CH3:22])([CH3:23])[CH2:13][N:14]1[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]1)=[O:9]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 7914Diisopropyl EtherHCID 15718253HCID 15718253, compound

Product 1

HCID 15718250HCID 15718250, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

460 mg of 3-(4-formyl-1-piperazinyl)-2,2-dimethylpropyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate was dissolved in 1.5 ml of methanol and 0.3 ml of an ethanol solution of 9.9H hydrogen chloride was added. After stirring the mixed solution for one night, isopropyl ether was added. The solid which separated was collected by filtration, dissolved in saturated aqueous sodium bicarbonate and extracted with ethyl acetate. After washing with saturated solution of sodium chloride, the extract was dried with anhydrous sodium sulfate; then, the solvent was evaporated under reduced pressure to give 350 mg of the subject compound (yield: 81%).

Workup

  1. customThe solid which separated
  2. filtrationwas collected by filtration
  3. dissolutiondissolved in saturated aqueous sodium bicarbonate
  4. extractionextracted with ethyl acetate
  5. washAfter washing with saturated solution of sodium chloride
  6. dry with materialthe extract was dried with anhydrous sodium sulfate
  7. customthen, the solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-a201dbe5b7c44ac0a9451965eb97a5ca
Source dataset
uspto-grants-1990_06
Patent number
US04937242

Reaction notes

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