Pyrrolidine → HCID 23045568, compound

HRID 2108154Notes

Reaction equation

HRID 2108154 reaction equation
CC(C)[CH2:3][O:4]CC1OC1.N1CCCC1.C[CH:16]([CH3:28])[CH2:17][O:18][CH2:19][CH:20]([OH:27])[CH2:21][N:22]1[CH2:26][CH2:25][CH2:24][CH2:23]1>C(O)C>[CH3:3][O:4][CH:16]([CH3:28])[CH2:17][O:18][CH2:19][CH:20]([OH:27])[CH2:21][N:22]1[CH2:23][CH2:24][CH2:25][CH2:26]1

Participants

5

Reactant 3

HCID 31268PyrrolidineHCID 981552-[(2-Methylpropoxy)methyl]oxiraneHCID 64521401-(2-Methylpropoxy)-3-(pyrrolidin-1-yl)propan-2-ol

Product 1

HCID 23045568HCID 23045568, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

20 g. 1-(2-Methylpropoxy)-2,3-epoxypropane are dissolved in 40 ml. ethanol and the solution is warmed to 55° C. Subsequently, in the course of an hour and while stirring, there is added dropwise a solution of 13 g. pyrrolidine in 25 ml. ethanol. The temperature should thereby not increase above 70° C. After completion of the addition, stirring is continued for 1 hour at 70° C., the reaction mixture is then evaporated and the residue is distilled in a vacuum. There are obtained 35 g. 3-(2-methylpropoxy)-1-pyrrolidinopropan-2-ol; b.p. 134° C./14 mm.Hg.

Workup

  1. additionthere is added dropwise a solution of 13 g
  2. temperatureThe temperature should thereby not increase above 70° C
  3. additionAfter completion of the addition
  4. stirringstirring
  5. customthe reaction mixture is then evaporated
  6. distillationthe residue is distilled in a vacuum
  7. customThere are obtained 35 g

Sources & evidence

ORD record
ord-fbbd07111a674f5b8bec9d2be9883c85
Source dataset
uspto-grants-1990_06
Patent number
US04937337

Reaction notes

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