Piperazine → 5-Iodo-2-(piperazin-1-yl)pyrimidine

HRID 2108162Notes

Reaction equation

HRID 2108162 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([I:8])=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>CN(C)C=O>[I:8][C:5]1[CH:4]=[N:3][C:2]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:7][CH:6]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 17142232-Chloro-5-iodopyrimidine

Product 1

HCID 157298765-Iodo-2-(piperazin-1-yl)pyrimidine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.02 mol of 2-chloro-5-iodopyrimidine, 0.06 mol of piperazine and 100 ml of absolute dimethylformamide are heated to 100° for 45 minutes and then evaporated. The crystalline residue is shaken with potassium bicarbonate solution and methylene chloride. The substance contained in the methylene chloride phase is purified by column chromatography over silica gel 60. The amine obtained by elution with methylene chloride/methanol (7:3) is stirred with isopropyl ether and filtered off with suction.

Workup

  1. customevaporated
  2. customis purified by column chromatography over silica gel 60

Sources & evidence

ORD record
ord-e687f32e07f74c639c66782c91aa894f
Source dataset
uspto-grants-1990_06
Patent number
US04937343

Reaction notes

Loading…