Potassium Carbonate → HCID 86744043, compound

HRID 2108166Notes

Reaction equation

HRID 2108166 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9](=[O:11])(=[O:10])[N:8]([CH2:12][CH2:13][CH2:14]Br)[C:7](=[O:16])[C:6]=2[CH:17]=1.[N:18]1[CH:23]=[CH:22][CH:21]=[N:20][C:19]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[N:18]1[CH:23]=[CH:22][CH:21]=[N:20][C:19]=1[N:24]1[CH2:29][CH2:28][N:27]([CH2:14][CH2:13][CH2:12][N:8]2[C:7](=[O:16])[C:6]3[CH:17]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=3[S:9]2(=[O:11])=[O:10])[CH2:26][CH2:25]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 887471-(2-Pyrimidinyl)piperazineHCID 19023372HCID 19023372, compound

Product 1

HCID 86744043HCID 86744043, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.03 mol of 5-fluoro-2-(3-bromopropyl)-1,2-benzisothiazol-3(2H)one 1,1-dioxide and 0.03 mol of 1-(2-pyrimidinyl)piperazine are stirred at 50° to 60° C. with 0.03 mol of K2CO3 in 100 ml of absolute DMF for 2 hours. The mixture is then evaporated, water is added to the residue and the base is extracted with methylene chloride. Purification is carried out by chromatography on silica gel; the eluting agent is CH2Cl2 /CH3OH (98:2), recrystallisation is on roluol.

Workup

  1. customThe mixture is then evaporated
  2. additionwater is added to the residue
  3. extractionthe base is extracted with methylene chloride
  4. customPurification
  5. customCH2Cl2 /CH3OH (98:2), recrystallisation

Sources & evidence

ORD record
ord-958ef92eb695471a95c89c4481f55dc7
Source dataset
uspto-grants-1990_06
Patent number
US04937343

Reaction notes

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