Hydrochloric Acid → HCID 131727384, compound

HRID 2108496Notes

Reaction equation

HRID 2108496 reaction equation
CN1CCC/C/1=C1/C=NC2C/1=CC=C(C(O)=O)C=2.[ClH:19].C[O:21][C:22]([C:24]1[CH:32]=[C:31]2[C:27]([C:28]([CH:33]3[CH2:37][CH2:36][CH2:35][N:34]3[CH2:38][C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)=[CH:29][NH:30]2)=[CH:26][CH:25]=1)=[O:23].O[Li].O>>[ClH:19].[CH2:38]([N:34]1[CH2:35][CH2:36][CH2:37][CH:33]1[C:28]1[C:27]2[C:31](=[CH:32][C:24]([C:22]([OH:23])=[O:21])=[CH:25][CH:26]=2)[NH:30][CH:29]=1)[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 68564569HCID 68564569, compoundHCID 68565781HCID 68565781, compound

Product 1

HCID 131727384HCID 131727384, compound

Procedure

According to the procedure described for synthesis of 3-[1-methyl-pyrrolidin-(2Z)-ylidene]-3H-indole-6-carboxylic acid; hydrochloride (example 35, step 2) the title compound was prepared from 3-(1-benzyl-pyrrolidin-2-yl)-1H-indole-6-carboxylic acid methyl ester and LiOH.H2O. MS (m/e): 321.1 (MH+).

Sources & evidence

ORD record
ord-99d4f56d56d346d7be69714e43dcf1f0
Source dataset
uspto-grants-2009_04
Patent number
US07514433B2

Reaction notes

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