反应详情

2-Cyano-3-hydroxypyridine (5.00 g) is dissolved in acetone (50 ml), and thereto are added methyl bromoacetate (7.0 g) and potassium carbonate (6.3 g). The mixture is heated under reflux for 1.5 hours. After allowing to cool, ice-water is poured to the reaction solution and extracted with ethyl acetate. The organic layer is washed with saturated brine, dried over sodium sulfate and evaporated to remove the solvent under reduced pressure. The resulting residue is suspended in diethyl ether/n-hexane and the solid is collected by filtration to give the title compound (7.91 g).

1. temperatureThe mixture is heated
2. temperatureunder reflux for 1.5 hours
3. temperatureto cool
4. extractionextracted with ethyl acetate
5. washThe organic layer is washed with saturated brine
6. dry with materialdried over sodium sulfate
7. customevaporated
8. customto remove the solvent under reduced pressure
9. filtrationthe solid is collected by filtration