Dimethylformamide → HCID 68861780, compound

HRID 2109407Notes

Reaction equation

HRID 2109407 reaction equation
[C:1]1([C:7]2[C:8]([CH:16]=[CH2:17])=[C:9]([C:12]([NH:14][NH2:15])=[O:13])[O:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CN([CH:21]=[O:22])C>C(OCC)(=O)C>[C:12]([C:9]1[CH:8]=[C:7]([CH:1]=[CH:2][C:21]=1[OH:22])[C:11]([NH:15][NH:14][C:12]([C:9]1[O:10][CH:11]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]=1[CH:16]=[CH2:17])=[O:13])=[O:10])#[N:14]

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 68861479HCID 68861479, compound

Product 1

HCID 68861780HCID 68861780, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 4-phenyl-3-vinyl-2-furancarboxylic acid hydrazide (compound of Reference Example 39, 0.20 g) and the compound of Reference Example 63 (0.32 g) in DMF (5 ml) was stirred at 70° C. for 3 hours. The reaction solution was diluted with ethyl acetate, washed with water, and dried over MgSO4. The solvent was evaporated under reduced pressure, and the residue was recrystallized from ethyl acetate, thereby giving 0.17 g of the desired compound. Melting point: 170-174° C.

Workup

  1. customwas stirred at 70° C. for 3 hours
  2. washwashed with water
  3. dry with materialdried over MgSO4
  4. customThe solvent was evaporated under reduced pressure
  5. customthe residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-d6f57990a1d24c759274c26e82e4dd3d
Source dataset
uspto-grants-2009_04
Patent number
US07514452B2

Reaction notes

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