Hydrochloric Acid → HCID 21959667, compound

HRID 2109641Notes

Reaction equation

HRID 2109641 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([NH:13][C:14](=[O:31])[C:15]3[CH:20]=[CH:19][CH:18]=[N:17][C:16]=3[NH:21][C:22]3[CH:30]=[C:29]4[C:25]([CH:26]=[N:27][NH:28]4)=[CH:24][CH:23]=3)[CH:11]=2)[C:6]([CH3:33])([CH3:32])[CH2:5]1)(=O)C.Cl>CCO>[CH3:32][C:6]1([CH3:33])[C:7]2[C:12](=[CH:11][C:10]([NH:13][C:14](=[O:31])[C:15]3[CH:20]=[CH:19][CH:18]=[N:17][C:16]=3[NH:21][C:22]3[CH:30]=[C:29]4[C:25]([CH:26]=[N:27][NH:28]4)=[CH:24][CH:23]=3)=[CH:9][CH:8]=2)[NH:4][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10160462HCID 10160462, compound

Product 1

HCID 21959667HCID 21959667, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-(1-Acetyl-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-(1H-indazol-6-ylamino)-nicotinamide (500 mg) was deprotected heating with 12 N HCl (3 ml) and EtOH (3 ML) at reflux for 1 h. Dried under vacuum and purified via HPLC. M+H 399.3; Calc'd for C23H22N6O: 398.2.

Workup

  1. temperatureat reflux for 1 h
  2. customDried under vacuum
  3. custompurified via HPLC

Sources & evidence

ORD record
ord-1f3b006d0983491fb4c61ab77d696004
Source dataset
uspto-grants-2009_04
Patent number
US07514564B2

Reaction notes

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