反应详情

To a cold (0° C.) solution of 2-[(benzyloxy)methyl]-1-tritylaziridine (1.28 g, 3.16 mmol) in dichloromethane (13 mL), trifluoroacetic acid (1 mL) and triethylsilane (2.0 mL) was added and stirred at the temperature for 1 h. The resultant mixture was concentrated under vacuum, and the residue was partitioned between ether and brine. The organic extract was dried with anhydrous magnesium sulfate, filtered, and concentrated under vacuum. The residue was subjected to column chromatography on silica gel eluting with a mixture of 50-100% THF in hexane. Collection and concentration of appropriate fractions provided 2-[(benzyloxy)methyl]aziridine.

1. concentrationThe resultant mixture was concentrated under vacuum
2. customthe residue was partitioned between ether and brine
3. extractionThe organic extract
4. dry with materialwas dried with anhydrous magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated under vacuum
7. additionThe residue was subjected to column chromatography on silica gel eluting with a mixture of 50-100% THF in hexane
8. customCollection and concentration of appropriate fractions