Piperazine → HCID 135481186, compound

HRID 2109883Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[CH:13][C:14]([O:16][CH3:17])=[CH:15][C:9]=3[C:8](=O)[NH:7][C:6]=2[CH:19]=1.[NH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[CH:13][C:14]([O:16][CH3:17])=[CH:15][C:9]=3[C:8]([N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)=[N:7][C:6]=2[CH:19]=1

Participants

Reactant 2

HCID 4837Piperazine

HCID 827174HCID 827174, compound

Product 1

HCID 135481186HCID 135481186, compoundYield 55.4%

Procedure

8-Chloro-2-methoxy-5,10-dihydro-dibenzo[b,e][1,4]diazepine-11-one (28 mg, 0.1 mmol) and piperazine (86 mg, 1.0 mmol) were reacted according to GP4 to give 19 mg of the title compound (160FE20A). MS (ESI) 342 (MH+). Purity for MH+ (UV/MS) 99/100.

Sources & evidence

ORD record: ord-3d3887285d6f477a9072d72422b5996a
Source dataset: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07517871B2

Reaction notes

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