Ethanol → HCID 86601389, compound

HRID 2110101Notes

Reaction equation

HRID 2110101 reaction equation
[CH3:1][NH2:2].C(O)C.Cl[C:7]1[C:12]([NH2:13])=[C:11]([Cl:14])[N:10]=[CH:9][N:8]=1>C(N(CC)CC)C>[NH2:13][C:12]1[C:7]([CH2:1][NH2:2])=[N:8][CH:9]=[N:10][C:11]=1[Cl:14]

Participants

5

Reactant 3

HCID 702EthanolHCID 6329MethylamineHCID 794345-Amino-4,6-dichloropyrimidine

Product 1

HCID 86601389HCID 86601389, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Conditions

Temperature
80 °C

Procedure

To 1 mL of methylamine, cooled at −80° C. in a steel vial, ethanol (13 mL) and triethylamine (1.3 mL) were added. Commercially available 4,6-dichloro-pyrimidin-5-yl-amine (3.0 mmol) was added to the solution and the reaction mixture heated at 80° C. for 3 hours. The solvent was removed in vacuo, and the resulting compound, (5-amino-6-chloropyrimidin-4-yl)methylamine, was obtained after silica gel chromatography and/or crystallization.

Workup

  1. additionwere added
  2. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-20ca34b07e9f47d7a2c68e0c078fa922
Source dataset
uspto-grants-2009_04
Patent number
US07517888B2

Reaction notes

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