Hydrogen Bromide → 4-Bromo-1-(difluoromethoxy)-2-methylbenzene

Temperature

0 °C

To a stirred solution of 4-amino-1-difluoromethoxy-2-methyl-benzene (5 g, 28.90 mmol) in HBr (20 mL) and water (20 mL) at 0° C. was added a solution of sodium nitrite (2.07 g, 30.00 mmol) in H2O (10 ml) dropwise over a period of 20 minutes. After the addition was complete, the reaction mixture was stirred for 30 minutes at 0° C. Copper (I) bromide (4 g, 27.87 mmol) was then added and the mixture was heated at 60° C. for 30 minutes. The resulting solution was extracted with EtOAc (3×50 mL) and the combined organic layers washed with H2O (1×20 mL), dried over Na2SO4 and concentrated to provide 2.5 g (37%) of 4-bromo-1-(difluoromethoxy)-2-methylbenzene.

1. additionAfter the addition
2. temperaturethe mixture was heated at 60° C. for 30 minutes
3. extractionThe resulting solution was extracted with EtOAc (3×50 mL)
4. washthe combined organic layers washed with H2O (1×20 mL)
5. dry with materialdried over Na2SO4
6. concentrationconcentrated

ORD record

ord-53a4e676e9af458f8933b289d9414ad9

Source dataset

uspto-grants-2009_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07517884B2