Hydrochloric Acid → HCID 136383508, compound

HRID 2110595Notes

Reaction equation

HRID 2110595 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH:17][C:18](=[O:28])[CH2:19][NH:20]C(=O)OC(C)(C)C)([CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15])[C:4](=[O:29])[C:3]=1[C:30]1[NH:35][C:34]2[CH:36]=[CH:37][C:38]([NH:40][S:41]([CH3:44])(=[O:43])=[O:42])=[CH:39][C:33]=2[S:32](=[O:46])(=[O:45])[N:31]=1.Cl>O1CCOCC1>[NH2:20][CH2:19][C:18]([NH:17][C:5]1([CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15])[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([OH:1])=[C:3]([C:30]2[NH:35][C:34]3[CH:36]=[CH:37][C:38]([NH:40][S:41]([CH3:44])(=[O:42])=[O:43])=[CH:39][C:33]=3[S:32](=[O:45])(=[O:46])[N:31]=2)[C:4]1=[O:29])=[O:28]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136383509HCID 136383509, compound

Product 1

HCID 136383508HCID 136383508, compoundYield 103.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of the product of Example 45 (4 mg, 0.0059 mmol) and 4 N HCl in dioxane (0.25 mL) was stirred at room temperature for 2 h. After which, the solution was concentrated in vacuo to afford the title compound as a white solid (3.5 mg, 97%). 1H NMR (300 MHz, DMSO-d6) δ ppm 0.57-0.74 (m, 6H), 0.79-0.94 (m, 1H), 1.19-1.39 (m, 2H), 1.75-1.90 (m, 1H), 1.92-2.12 (m, 1H), 3.05 (s, 3H), 7.42-7.66 (m, 5H), 7.88-7.97 (m, 2H), 8.10 (d, J=7.72 Hz, 1H), 9.39 (s, 1H), 10.15 (s, 1H), 14.19 (s, 1H); MS m/z 575.7 (M+H)+.

Workup

  1. concentrationAfter which, the solution was concentrated in vacuo

Sources & evidence

ORD record
ord-fedf7fa4a1bb4624b5b526fb6d35ed21
Source dataset
uspto-grants-2009_04
Patent number
US07517876B2

Reaction notes

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