HCID 23157275, compound → HCID 23160005, compound

HRID 2110868Notes

Reaction equation

HRID 2110868 reaction equation
[C:1]([C:5]1[CH:9]=[C:8]([O:10]CC2C=CC(C(OC)=O)=CC=2)[N:7]([CH2:22][C:23]2[CH:32]=[CH:31][C:26]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][CH:24]=2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2]>[C].[Pd].O1CCCC1>[C:1]([C:5]1[CH2:9][C:8](=[O:10])[N:7]([CH2:22][C:23]2[CH:24]=[CH:25][C:26]([C:27]([O:29][CH3:30])=[O:28])=[CH:31][CH:32]=2)[N:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 23157275HCID 23157275, compound

Product 1

HCID 23160005HCID 23160005, compoundYield 81.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of methyl 4-[(3-tert-butyl-5-{[4-(methoxycarbonyl)benzyl]oxy}-1H-pyrazol-1-yl)methyl]benzoate (6.90 g, 15.8 mmol), 10% palladium-carbon (50% water-containing product, 0.35 g) and tetrahydrofuran (50 mL) was stirred overnight at room temperature under a hydrogen atmosphere. The catalyst was filtered off and the obtained filtrate was concentrated to give the title compound (3.70 g, yield 81%) as colorless crystals. melting point 161-162° C.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe obtained filtrate was concentrated

Sources & evidence

ORD record
ord-035be46aa9be44679ef2cd09b9e1f8e7
Source dataset
uspto-grants-2009_04
Patent number
US07517910B2

Reaction notes

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