Methyl Methacrylate → HCID 57635055, compound

HRID 2111241Notes

Reaction equation

HRID 2111241 reaction equation
[CH:1]1([NH2:5])[CH2:4][CH2:3][CH2:2]1.[C:6]([O:11][CH3:12])(=[O:10])[C:7]([CH3:9])=[CH2:8]>CO>[CH3:12][O:11][C:6](=[O:10])[CH:7]([CH3:9])[CH2:8][NH:5][CH:1]1[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6658Methyl MethacrylateHCID 75645Cyclobutylamine

Product 1

HCID 57635055HCID 57635055, compoundYield 80.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 10.72 g (0.10 mole) of cyclobutylamine, 12.01 g (0.12 mole) of methyl methacrylate and 50 mL of methanol was heated at 90 degrees for 20 hours in a pressure bottle. After cooling the mixture was concentrated, then distilled under vacuum to give 13.77 g of (rac)-3-cyclobutylamino-2-methyl-propanoic acid methyl ester as colorless oil. b.p. 70-75 degrees at 0.5 mm Hg.

Workup

  1. temperatureAfter cooling the mixture
  2. concentrationwas concentrated
  3. distillationdistilled under vacuum

Sources & evidence

ORD record
ord-ef06929c60c249e5912e966f4ee1fbe3
Source dataset
uspto-grants-2009_04
Patent number
US07517873B2

Reaction notes

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