Methyl Methacrylate → HCID 43398417, compound

HRID 2111242Notes

Reaction equation

HRID 2111242 reaction equation
[CH2:1]([NH2:6])[CH2:2][CH:3]([CH3:5])[CH3:4].[C:7]([O:12][CH3:13])(=[O:11])[C:8]([CH3:10])=[CH2:9]>CO>[CH3:13][O:12][C:7](=[O:11])[CH:8]([CH3:10])[CH2:9][NH:6][CH2:1][CH2:2][CH:3]([CH3:5])[CH3:4]

Participants

4

Reactant 2

HCID 6658Methyl MethacrylateHCID 7894Isoamylamine

Product 1

HCID 43398417HCID 43398417, compoundYield 76.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 8.72 g (0.10 mole) of isoamylamine, 12.01 g (0.12 mole) of methyl methacrylate and 50 mL of methanol was heated at reflux under an argon atmosphere for 22 hours. After cooling the mixture was concentrated, then distilled under vacuum to give 14.31 g of (rac)-2-methyl-3-(3-methyl-butylamino)-propanoic acid methyl ester as colorless oil. b.p. 73-75 degrees, 2 mm Hg.

Workup

  1. temperatureat reflux under an argon atmosphere for 22 hours
  2. temperatureAfter cooling the mixture
  3. concentrationwas concentrated
  4. distillationdistilled under vacuum

Sources & evidence

ORD record
ord-2411a048f46b42d48ea5790f0f7aad00
Source dataset
uspto-grants-2009_04
Patent number
US07517873B2

Reaction notes

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