反应详情

To a mixture of 0.056 g (0.0002 mole) of (rac)-2-chloro-9-cyclopentyl-7-methyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one, 0.5 mL of N,N-dimethylacetamide and 0.018 mL (0.0003 mole) of iodomethane was added 0.012 g (0.0003 mole) of 60% sodium hydride in oil at 0 degrees. The mixture was stirred at ambient temperature for 1 hour, then 10 mL of water was added. The precipitate collected by filtration to give 0.049 g of (rac)-2-chloro-9-cyclopentyl-5,7-dimethyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one (VI-1) as an yellow solid.

1. filtrationThe precipitate collected by filtration