1-Benzyl-4-piperidone → HCID 59003394, compound

HRID 2111603Notes

Reaction equation

HRID 2111603 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:4][CH:3]=1.C([Li])CCC.[CH2:18]([N:25]1[CH2:30][CH2:29][C:28](=[O:31])[CH2:27][CH2:26]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C1COCC1.CCCCCC>[CH2:18]([N:25]1[CH2:30][CH2:29][C:28]([C:2]2[CH:7]=[CH:6][C:5]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:4][CH:3]=2)([OH:31])[CH2:27][CH2:26]1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

6

Reactant 3

HCID 192201-Benzyl-4-piperidoneHCID 5210081-Bromo-4-(trifluoromethoxy)benzeneHCID 178418339Butyllithium

Product 1

HCID 59003394HCID 59003394, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolvent2×HCID 8058HexaneSolvent

Procedure

This compound is prepared according to the procedure described in step A of Preparation 8.5, starting with 20 g of 1-bromo-4-(trifluoromethoxy)benzene in 300 ml of THF, 89.3 ml of a 1.6M solution of n-butyllithium in hexane and 24.1 ml of 1-benzyl-4-piperidinone in 50 ml of THF. 18.5 g of the expected product are obtained.

Workup

  1. customThis compound is prepared
  2. customdescribed in step A of Preparation 8.5

Sources & evidence

ORD record
ord-82b1bcd997d0412cb4738990d893cbda
Source dataset
uspto-grants-2009_04
Patent number
US07521449B2

Reaction notes

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