HCID 86603558, compound → HCID 68919313, compound

HRID 2111636Notes

Reaction equation

HRID 2111636 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[CH3:11])[C:7](=[O:12])[N:6]([C:13]1[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=1)[CH:5]2[CH2:19][CH2:20]OS(C)(=O)=O>C(N)CC>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[CH3:11])[C:7](=[O:12])[N:6]([C:13]1[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=1)[CH:5]2[CH2:19][CH2:20][NH:6][CH2:5][CH2:4][CH3:3]

Participants

3

Reactant 1

HCID 86603558HCID 86603558, compound

Product 1

HCID 68919313HCID 68919313, compoundYield 169.6%

Reagents, catalysts & solvents 1

HCID 7852PropylamineSolvent

Procedure

5,6-Dimethyl-2-(3-pyridyl)-3-mesyloxyethylisoindolin-1-one (0.11 g, 0.31 mmol) was stirred in n-propylamine (3 ml) at 25° C. for 6 hrs. The reaction solution was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (chloroform:methanol=15:1) to give 85 mg of the title compound.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe residue was purified by silica gel chromatography (chloroform:methanol=15:1)

Sources & evidence

ORD record
ord-813d2aca12dd4d15904ece5d11bfa43d
Source dataset
uspto-grants-2009_04
Patent number
US07521451B2

Reaction notes

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