反应详情

4-(2-Hydroxyethyl)phenol (2 g, 14.48 mmol) and methyl 2-(bromomethyl)benzoate (3.48 g, 15.20 mmol) were dissolved in acetonitrile (20 ml). Potassium carbonate anhydrous (4.0 g, 28.95 mmol) was added. After stirring at 60° C. for three hours PS-trisamine was added (0.2 eq) and the mixture was stirred overnight. The PS-trisamine was filtered off and the acetonitrile was removed by evaporation. EtOAc (10 ml) was added and the organic layer was washed with 3 portions of water (3×10 ml). The organic phase was dried (MgSO4) and the solvent was removed by evaporation to give 3.732 g of methyl 2-{[4-(2-hydroxyethyl)phenoxy]methyl}benzoate (yield 90%).

1. additionwas added (0.2 eq)
2. filtrationThe PS-trisamine was filtered off
3. customthe acetonitrile was removed by evaporation
4. additionEtOAc (10 ml) was added
5. washthe organic layer was washed with 3 portions of water (3×10 ml)
6. dry with materialThe organic phase was dried (MgSO4)
7. customthe solvent was removed by evaporation