反应详情

温度

60 °C

4-(3-Hydroxypropyl)phenol (1.0 g, 6.57 mmol) and methyl 2-(bromomethyl)benzoate (1.66 g, 7.23 mmol) was dissolved in acetonitrile (10 ml). Potassium carbonate (1.82 g, 13.14 mmol) was added and the mixture was stirred at 60° C. for three hours. Polymer supported trisamine (0.3 eqv) was added and the solution was stirred at room temperature over night. The PS-trisamine was filtered of and the acetonitrile was removed by evaporation. EtOAc (10 ml) was added and the organic layer was washed with 3 portions of water (3×10 ml). The organic phase was dried (MgSO4) and the solvent was removed by evaporation to give 1.66 gram of methyl 2-{[4-(3-hydroxypropyl)phenoxy]-methyl}benzoate (yield 84.2%).

1. additionwas added
2. stirringthe solution was stirred at room temperature over night
3. filtrationThe PS-trisamine was filtered of and the acetonitrile
4. customwas removed by evaporation
5. additionEtOAc (10 ml) was added
6. washthe organic layer was washed with 3 portions of water (3×10 ml)
7. dry with materialThe organic phase was dried (MgSO4)
8. customthe solvent was removed by evaporation