反应详情

18.7 g (100 mmol) tert.butyl (3-hydroxy-cyclobutyl)-carbamate and 12.1 g (120 mmol) triethylamine are placed in 500 ml chloroform. 20.5 g (105 mmol) tosyl chloride, dissolved in 150 ml chloroform, is added dropwise to this solution at 0° C. with stirring. Then the mixture is left to come up to ambient temperature and stirred for 2 h. The organic phase is washed successively with water, dilute hydrochloric acid, sodium hydrogen carbonate solution and water. The organic phase is dried with magnesium sulphate and the solvent is eliminated in vacuo.

1. additionis added dropwise to this solution at 0° C.
2. waitThen the mixture is left
3. customto come up to ambient temperature
4. stirringstirred for 2 h
5. washThe organic phase is washed successively with water, dilute hydrochloric acid, sodium hydrogen carbonate solution and water
6. dry with materialThe organic phase is dried with magnesium sulphate