HCID 86606184, compound → HCID 57640192, compound

HRID 2112096Notes

Reaction equation

HRID 2112096 reaction equation
C([N:8](CC1C=CC=CC=1)[C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:18]=1[C:17](=[O:19])[N:16]([CH2:20][CH2:21][F:22])[CH2:15][CH2:14]2)C1C=CC=CC=1>CO.[OH-].[Pd+2].[OH-]>[NH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:18]=1[C:17](=[O:19])[N:16]([CH2:20][CH2:21][F:22])[CH2:15][CH2:14]2

Participants

4

Reactant 1

HCID 86606184HCID 86606184, compound

Product 1

HCID 57640192HCID 57640192, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

830 mg (2.136 mmol) 8-dibenzylamino-2-(2-fluoro-ethyl)-3,4-dihydro-2H-isoquinolin-1-one are dissolved in 50 ml of methanol and combined with 80 mg palladium hydroxide. The reaction mixture is stirred for 48 h at ambient temperature and 4.5 bar H2 pressure. Then the catalyst is filtered off and the solvent is eliminated in vacuo.

Workup

  1. filtrationThen the catalyst is filtered off

Sources & evidence

ORD record
ord-b9bba480b1be4c8689314bb5dc7d9bfd
Source dataset
uspto-grants-2009_04
Patent number
US07521457B2

Reaction notes

Loading…